Robert J Unwin Selected Research

Fanconi Syndrome (Syndrome, Fanconi)

1/2021	Predicting the protein composition of human urine in normal and pathological states: Quantitative description based on Dent1 disease (CLCN5 mutation).
1/2018	Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.
9/2008	Lysosomal enzymuria is a feature of hereditary Fanconi syndrome and is related to elevated CI-mannose-6-P-receptor excretion.
8/2007	Combined proteomic and metabonomic studies in three genetic forms of the renal Fanconi syndrome.
6/2005	Renal tubular acidosis: developments in our understanding of the molecular basis.
11/2004	Quantitative amino acid and proteomic analysis: very low excretion of polypeptides >750 Da in normal urine.
9/2004	The urinary proteome in Fanconi syndrome implies specificity in the reabsorption of proteins by renal proximal tubule cells.
5/2003	Detection and analysis of urinary peptides by on-line liquid chromatography and mass spectrometry: application to patients with renal Fanconi syndrome.
7/2002	Fragmentation of filtered proteins and implications for glomerular protein sieving in Fanconi syndrome.
1/2002	Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome.

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Robert J Unwin Research Topics

Disease

10	Fanconi Syndrome (Syndrome, Fanconi) 01/2021 - 01/2002
9	Hypertension (High Blood Pressure) 01/2022 - 07/2004
8	Proteinuria 01/2021 - 01/2002
7	Inflammation (Inflammations) 12/2019 - 07/2011
5	Renal Tubular Acidosis (Distal Renal Tubular Acidosis) 01/2021 - 01/2002
5	Renal Insufficiency (Renal Failure) 12/2019 - 11/2004
5	Fibrosis (Cirrhosis) 01/2018 - 07/2014
5	Glomerulonephritis 07/2014 - 02/2007
5	Dent Disease 09/2008 - 01/2002
4	Kidney Diseases (Kidney Disease) 05/2022 - 12/2008
3	Kidney Calculi (Kidney Stone) 01/2022 - 01/2012
3	Acidosis 01/2021 - 06/2005
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 03/2002
3	Sepsis (Septicemia) 01/2018 - 01/2014
3	Acute Kidney Injury (Acute Renal Failure) 01/2018 - 08/2017
3	Familial Hypophosphatemia (Phosphate Diabetes) 01/2017 - 02/2008
3	Cysts 01/2007 - 03/2003
2	Weight Loss (Weight Reduction) 02/2021 - 01/2011
2	Nephrocalcinosis 01/2021 - 06/2005
2	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 10/2011
2	Albuminuria 01/2021 - 11/2015
2	Rickets (Rachitis) 01/2021 - 06/2005
2	Peritonitis 01/2018 - 08/2017
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2018 - 03/2015
2	Diabetic Nephropathies (Diabetic Nephropathy) 05/2017 - 01/2016
2	Hypoxia (Hypoxemia) 11/2015 - 01/2014
2	Nephritis 07/2014 - 02/2007
2	Reperfusion Injury 01/2014 - 07/2011
2	Infections 01/2014 - 01/2012
2	Hyperphosphatemia 07/2013 - 08/2010
2	Chronic Renal Insufficiency 07/2013 - 10/2010
2	Chronic Kidney Failure (Chronic Renal Failure) 10/2010 - 08/2010
2	Oculocerebrorenal Syndrome (Lowe Syndrome) 09/2008 - 11/2004
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2022
1	Obesity 02/2021
1	Iron Deficiencies 01/2021
1	Failure to Thrive 01/2021
1	Ischemia 01/2021
1	Hearing Loss (Hearing Impairment) 01/2021
1	COVID-19 01/2021
1	Alkalosis 01/2019
1	Fever (Fevers) 01/2018
1	Tachycardia (Tachyarrhythmias) 01/2018
1	Glucose Intolerance 01/2018
1	Hypercalciuria 12/2017
1	Nephrolithiasis 12/2017
1	Hyperglycemia 05/2017
1	Chronic Disease (Chronic Diseases) 01/2017

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 02/2021 - 01/2002
8	Adenosine Triphosphate (ATP)IBA 01/2020 - 03/2003
8	Purinergic P2X7 ReceptorsIBA 12/2019 - 02/2007
6	Phosphates (Orthophosphate)IBA 01/2021 - 02/2008
5	Peptides (Polypeptides)IBA 01/2014 - 05/2003
4	Biomarkers (Surrogate Marker)IBA 05/2022 - 12/2008
4	SodiumIBA 01/2021 - 02/2011
4	CytokinesIBA 12/2019 - 07/2004
4	CreatinineIBA 01/2018 - 12/2009
3	AcidsIBA 01/2022 - 06/2005
3	Messenger RNA (mRNA)IBA 02/2021 - 02/2007
3	Glucose (Dextrose)FDA LinkGeneric 02/2021 - 01/2016
3	dirhodium tetraacetate (DRTA)IBA 01/2021 - 07/2002
3	AlbuminsIBA 01/2021 - 01/2014
3	InflammasomesIBA 12/2019 - 01/2014
3	salicylhydroxamic acid (SHAM)IBA 01/2018 - 10/2010
3	Purinergic Receptors (Receptors, Purine)IBA 01/2018 - 09/2004
3	ProteomeIBA 03/2015 - 09/2004
3	SaltsIBA 01/2013 - 10/2011
3	Calcineurin InhibitorsIBA 05/2012 - 10/2011
2	Bicarbonates (Hydrogen Carbonate)IBA 01/2022 - 01/2021
2	CalciumIBA 01/2021 - 12/2017
2	EnzymesIBA 01/2021 - 09/2008
2	calcium phosphateIBA 01/2021 - 06/2005
2	Vitamin D FDA LinkGeneric 01/2019 - 12/2017
2	Purinergic P2X4 ReceptorsIBA 10/2018 - 07/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 07/2011
2	Pharmaceutical PreparationsIBA 10/2011 - 03/2002
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Sodium-Glucose Transport ProteinsIBA 02/2021
1	Edetic Acid (EDTA)FDA Link 01/2021
1	Citric Acid (Citrate)FDA LinkGeneric 01/2021
1	oligomycin sensitivity-conferring protein (complex V)IBA 01/2020
1	OxalatesIBA 12/2019
1	AldosteroneIBA 01/2019
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2018
1	Serum AlbuminIBA 01/2018
1	Sweetening Agents (Sweeteners)IBA 01/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2018
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 01/2018
1	Oxygen (Dioxygen)IBA 01/2018
1	glycine amidinotransferase (arginine-glycine amidinotransferase)IBA 01/2018
1	NAD (NADH)IBA 01/2018
1	Lipocalin-2IBA 08/2017
1	Insulin-Like Growth Factor Binding ProteinsIBA 08/2017
1	Cystatin CIBA 08/2017
1	CalbindinsIBA 08/2017
1	CollagenIBA 05/2017
1	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 05/2017
1	Sodium-Phosphate Cotransporter Proteins (Sodium-Phosphate Cotransporter)IBA 01/2017
1	Parathyroid Hormone (Parathormone)IBA 01/2017

Therapy/Procedure

2	Gastric Bypass (Roux-en-Y Gastric Bypass) 02/2021 - 01/2011